One of the most important defense mechanisms the body has to guard itself against aging is a process called autophagy (8). Autophagy can be thought of as the body doing its own internal “housekeeping” so that all organ systems and processes continue to run smoothly. Old, damaged cell components are repaired or discarded so that cells can continue to function optimally. Autophagy in the body decreases as we age, so the body’s ability to self-help itself is reduced as well. Calorie restriction, including fasting, has been found to promote autophagy to mend the body’s cells (9). It’s as if the consumption of fewer calories allows the body to rest and to go into recovery mode. This has been proposed to be the reason why calorie restriction and fasting have an “anti-aging” effect.
The Isagenix diet will not deprive your body of any nutrients. Hence, you can follow your regular exercise routine or start working out whenever you get time. Warm-ups, walking, running, jogging, cycling, yoga, dancing, playing a sport, etc. will help secrete the good hormones. These, in turn, trigger metabolism and help you lose weight. You will look and feel good after a good workout of at least about 30 minutes.
Isagenix is all hype! Just eat “clean” foods; organic, non-processed fruits vegetable, whole grains (quinoa, brown rice, etc.)! Yes, the product has nutrients, but there is an absence of research studies. The only studies conducted are those by Isagenix, which is no good. If results are not replicated then how do we know something is really working, and not due to chance. Eat less calories by cutting out processed foods, and enjoy what mother nature gave to us :)..a perspective from a molecular biologist.
When you challenge a way people think and what they have been led to believe their entire life, it scares them to think they’ve been lied to (medical field, food manufacturers–I mean, really? If the food has been manufactured and made in a factory, how CAN that be REAL food?, people and corporations and chemical companies “out to feed the world and raise more food”–how is that working out for us, when we have people literally starving all over the world?). The whole concept of everything people have been told, taught, and have done their entire life isn’t necessarily the right or correct thing to be doing.
I have no obligation to give you nutrition advice. You leaving comments is still not enough information to give you advice, not that I would do that anyway. Normally my clients are required to fill out detailed medical histories, and might I remind you – you are not a client. Apparently you’re a really angry person (that’s unable to properly punctuate or insert paragraphs) seeking free advice.
My daughters have tried to get me to take this stuff. My husband is pre-diabetic and needs to lose weight. People in his family are predisposed to carry fat on their stomachs, men and women. I have studied nutrition for 30 years, and practiced it in my life. When they presented me with this, I thought it was just a trial. They said I could return it in 30 days. I was not told that it would “auto ship”. I tried one of the IsaDelights that we were “gifted” with and I found it to be intensely sweet. When I looked at the ingredients (mind you, this is to be taken on “cleanse” days, imagine my surprise to find the number one ingredient was sugar. When I looked at the list of “vitamins” on the cans, I saw folic acid, which is a synthetic that is detrimental to the body instead of folate. All these things were glossed over. That much sugar in just one “snack” (two were recommended) was way too big a hit of sugar for someone fighting elevated blood sugars. Why couldn’t they have used Stevia? Stevia doesn’t raise glucose levels and is about 0 carbs/calories. Fructose is cheaper. Soy is cheaper. These guys are scientists, but not necessarily nutritionists. This may take the weight off, or it might not. I think it depends on how motivated the person is. If you are going spend a fortune on this product, and to help pay for it you become a seller; (Kind of like vampirism, you get infected and pass it on), you want to be able to show the next guy that it works. So you work harder to lose the weight. So making money becomes the motivation. Best motivation in the world, but I am leery of MLM’s and their pyramids, which cause people to force their loved ones to buy something that is inferior to what they are already doing. Just because these people claim to be scientists doesn’t impress me. I can claim to be a scientist too. I can claim to be a Martian if I want to. Maybe people will believe me, maybe they won’t. I do not know any truly reputable people who have researched this thoroughly, who would give it a thumbs up. As a last resort, maybe, but it’s full of synthetics and GMOs. That is my opinion. We’ve tried it and it’s probably too late to get our money back.
The past two years has been tough for me and there’s been a lot of changes in my life. I’m going through a divorce, dealing with chronic pain and lack of medical help and working to build my business. Stress has taken its toll and unfortunately with that the weight slowly creeped up on me. I’m on two types of medication that cause weight gain so I have to be very vigilant with what I eat. I got to the point where I didn’t care anymore and just ate what I wanted when I wanted it.
Working with my GP we isolated anything new I had done, and we both noted Isagenix, so I went off this and straight away and after 4 days I dropped 5 points and after 9 days my blood pressure dropped into the safe zone – I started to feel normal again and breathed a huge relief. Not all programs are for all bodies and this was definitely not right for my body and caused me great alarm. Now I am taking a natural approach to health and walking most days for 30 mins, eating lots of raw foods, brown rice and making the changes using natural foods, and good old fashioned exercise. Many thanks for the opportunity to share my story on your blog site. Liz
Despite this, there are plenty of Isagenix 'fans' keen to sell, sell, sell on social media. Nikalene Riddle, who runs the healthy eating Facebook group Skinnymixers, says she's been 'bombarded' with Isagenix sellers. "What I dislike about this product and their sellers is they don't post publicly about it, they private message my members. They use this method because they know that advertising in my group is strictly forbidden, and if they promoted such a ridiculous product in a healthy eating group they would have hundreds of people calling them out. So instead they pick off people one by one until someone bites."
Unfortunately, here in the good old USA, you practically need to be a chemist, MD, nutritionist and scientist wrapped up in one who can determine what is or is not good to eat, what is whole and pure. Not only that, but you will need to take a few cooking courses to learn how to cook most of these wonderful whole foods which would be a replacement to the convenient packaged processed variety (Many American’s have long forgotten how to make anything from “scratch” with whole foods since the invention of the cardboard box and food processing). You know, make your own tea using only certified organic non-GMO herbs, weed out which foods have additives hidden in them but look to be good on the pretty packages taunting all natural, healthy, i.e. a simple can of tomato sauce with an ingredient list longer than my 7 year olds Christmas desires.
It’s interesting that all the weight loss magic pills and shakes all make the same claims. The latest is Thrive Le-vel. To listen to all the claims, it sounds like they’ve got the perfect pill to make you look and feel the best you ever have. These companies are all the same….they shut down one, only to slap on a new label and sell it again. Wish they would regulate supplements and what exactly is in them. Our dog and cat food is regulated better than our supplements.
But when I consciously choose to travel to far away countries, be accepted by the indigenous people and accept them in return, who hold ancient knowledge and wisdom for the future betterment and evolution of our species, do service to a community, to be part of a combined and soul felt movement for love, understanding, acceptance and peace, then I am SOMEBODY.
I was surprised to find that I didn’t feel hungry on the Cleanse Days even though I wasn’t really eating any food besides the snacks. On day one, John and I went shopping and he stopped at McDonalds drive-thru and ate his Big Mac meal right in front of me!! Not very nice of him at all, but I wasn’t really tempted. I was a woman on a mission to complete the 9 days with NO CHEATING! When I did feel hungry, I went for a glass of water and an Isagenix snack. It satisfied my hunger and gave me energy.

As a fellow Holistic Health coach, I am writing to express my support of your Isagenix review. The ignorant responses boggle my mind. Thank you for the accurate research and clear explanation. Please do not let any of the negative comments damper your spirits!! Keep up the good work and sharing the knowledge of the benefits of organic, clean eating!


I’m embarrassed and somewhat ashamed to admit that I was an Isagenix Associate for 2 years. I became aware of Isagenix through a friend (at the time) that I respected in the local fitness industry. I took only the main products (“Pillars of Health”), enrolled others, and for a while made some decent money. Luckily, I met another Certified Nutrition Consultant purely by chance during a layover at an airport and when I brought up Isagenix to her, because she knew a good amount about it from some of her clients that had come to her, she filled me in on many of the same “facts” (and I mean “facts” in a real and positive way) that you have mentioned throughout your blog. Well, of course, after meeting her I was bummed because I had so wanted to believe in Isagenix, and when I got home I spent hours doing research on my own – I had even taken notes at the airport. What the woman that I had met at the airport had told me was backed up by the research I did. Truthfully, there was always a part of me that didn’t feel comfortable with the whole thing, especially the 9 day and 30 day cleanse “systems” Isagenix highly promoted. I, personally, only sold a couple of the cleanse systems and one was to a good friend and he felt like crap during the 9 day cleanse and couldn’t wait until it was over. He did lose 3 pounds but like you said so many times, just because something makes you lose weight doesn’t make it healthy.
“A small amount of fructose, such as the amount found in most vegetables and fruits, is not a bad thing. In fact, there is evidence that a little bit may help your body process glucose properly. However, consuming too much fructose at once seems to overwhelm the body’s capacity to process it. The diets of our ancestors contained only very small amounts of fructose. These days, estimates are that about 10% of the modern diet comes from fructose.
I have just one tiny piece of information to add. I’m a medical librarian so I always like to find peer-reviewed studies to help illuminate an issue. There is still a lot of uncertainty about that whole fructose toxicity thing. Recent reviews of several studies found that there really isn’t enough evidence to show that fructose is causal for metabolic disease, clinical hepatic toxicity, etc. I don’t think the studies are saying we will never find a relationship, but that it’s too soon to make public health declarations or policy based on the science that exists. See:

Powerful multivitamin and mineral formula specifically designed to sustain and promote the best possible health for men. Contains ingredients such as zinc and selenium to help support prostate health. Includes premium B vitamins that help support a healthy immune system. Contains adaptogens, which support overall health while also helping to reduce symptoms of stress.


I really appreciate your information. I too had a hard time finding unbiased real information about Isagenix that did not come from their own website. I was always a skeptic about it, but got convinced after my friend lost a lot of weight and was really selling me on it. I argued with her about the ingredients, but still got convinced and ended up spending a small fortune I don’t have. It was too hard for me to stick to after a short time anyway….I am used to trying to eat healthy but by actually EATING real food and doing the shakes and all that just felt too restrictive to me.
I was in poor health and using the Isagenix products helped me lose weight, begin exercising, and make healthier food choices. I continue to use Isagenix products as part of a healthy lifestyle. Unlike Dr. Hall, I am not an MD, but with that being said, many of her criticisms of the Isagenix products are not really accessible to the average person. So, Dr. Hall, I guess since you are writing so much about Isagenix, maybe refer us readers to other health professionals, perhaps in the field of nutrition that can speak with more credibility, to what you are saying.

Also, for your further enjoyment you should look further into the lead levels of the shakes. They have been sited by California Prop 65 and have labeled all of their shakes accordingly. They have information on their website as to how they are still under the federal guidelines. They did in fact remove the soy lecithin from the shakes after what they described as “confusion” amongst people. Not stating that in fact soy lecithin contains trace amounts of soy proteins.


Organic agave nectar is relatively mild, is not chemically processed, and is free from harmful additives. This is the kind that Isagenix uses. Agave has beneficial properties which support digestive health. Agave contains naturally occurring inulin, a form of fructan found in a number of vegetables including onions, green beans, asparagus, and artichokes. The fructans in agave have been demonstrated to support the growth of beneficial microbial flora in the digestive tract. M.G. López and J.E. Urías-Silvas, “Prebiotic Effect Of Fructans From Agave, Dasylirion And Nopal,” ISHS International Symposium on Human Health Effects of Fruits and Vegetables (Québec City, Canada) 2007 (http://www.actahort.org/books/744/744_45.htm).
My very sweet friend has been suckered in by Isagenix. I have always known that “cleansing” and “toxins” were lies and used to sell products, but she raves about Isa being a whole food and full of nutrition. She is a nice person, so I was willing to hear her out even though I hate MLMs. All I had to do was read the ingredients list on the shakes – who actually thinks this is healthy? I tried googling and very little comes up about the products that isn’t positive. My friend added me to some Isagenix support groups on Facebook and what I have seen in them frightens me. It is cultish. These people are unnaturally positive. They do not necessarily make health claims, but they “share their personal experiences,” which end up being health claims. New members come in asking questions like, “I am hypoglycemic. Should I cleanse?” People tell them to cleanse, anyway and not doing so would be worse for them. They tell people that they need to take this stuff while pregnant (um – taking too much vitamin A while pregnant is dangerous, even if it is beta carotene). They talk about how doctors just don’t know anything about nutrition. Really? And THEY do? None of these people are physicians or nutritionists, and their knowledge of human nutrition comes only from reading Isagenix propaganda. They talk about how the FDA is corrupt so the fact that it isn’t FDA approved is a good thing. Are you kidding me? I am genuinely concerned about people I know and love and it scares me how they are more willing to listen to these companies that are profiting handsomely from them, than they are to listen to friends, family… And doctors. I wish I knew what to do. Thank you for providing this article. I hope more people will read it.
You have helped “trillions” of people, so you must be doing really well. Before your above comment I was actually really looking into your programs. Because of my background in health research ethics and governance it is natural for me question credibility of information. Before say my background does not qualify me to know anything about anything, I never said or suggested it does. Just that it is the reason I question information and motivations. If you don’t like being questioned about your opinion, don’t publish it. You have baited people to read your blog and then ambushing them when they have something to say about it, unless is it complementary to you and your business. Not unbiased in the slightest. This brings me back to the biggest point (which seems to be the elephant in the room for you) that your product reviews are not unbiased. You should not claim that they are. They are reviews, quite right there, but not unbiased. In a public health setting, ethically you could not claim this. It doesn’t matter how many people say “well done” or “you’re so right”. Let’s try it in the language that you would use, it is literally fact that you are non unbiased. Next time you review something, try harder to be unbiased. Maybe by posting in a blog that is not selling your own products. You have the upper hand here because you are the business owner and you could actually have more integrity. If you are questioning my integrity, question away, but I’m actually not selling anything.
Still freaking out… My mental turmoil led me to a Facebook group of other Isagenix cleansers for support—some of whom started their cleanses on the same day as my fiancé and I, while most were people who go on cleanses repeatedly. (Wait, people do this more than once?) Apparently, some even do it for 30 days at a time. I don’t think I’m quite that dedicated to my body or nutritional well-being. I'm happy to report I've lost 5 pounds so far (my fiance lost 12!). 

An Isagenix-funded study published in Nutrition & Metabolism in 2012 found that over an eight-week period, people who used Isagenix meal-replacement shakes as part of an intermittent fasting and calorie-restriction diet lost 2.2 pounds more than those who followed a similar diet using regular food. However, according to a 2012 article published on the Science-Based Medicine website, this study wasn't well-designed, and Isagenix paid to get it published in the journal. The author of the website article, Dr. Harriet Hall, also noted that there were inconsistencies in the numbers listed in the results, potentially making the conclusions unreliable.

My take on the idea of whole foods and avoiding excess fructose is actually right in line with yours. I do try to focus on whole foods for most of the meals I eat and I do not drink calories (soda) and try to minimize the sugar in my diet. Knowing that 50% of sucrose is fructose, I try to focus on the whole sugars. With Isagenix, my sugar intake overall has dropped, which is a good thing. It is a plan to aid me in achieving my goals. Could I achieve my goals with whole foods? I believe anyone could, but we have to be wise and strong. Sometimes we need a plan to help us, and that is was this is for me. I am intrigued by the energy increase I have felt, the weight loss I am starting to experience and the improved focus I have throughout my day. I don’t believe it is for everyone, but I do believe it is for some. My wife, for example, is hypoglycemic and has a dairy allergy. She struggles BIGTIME, and is trying Isagenix as an attempt to see if she can find some balance. Time will tell. Her best success has been on a ketogenic plan, so we’ll see how this goes.

Please remember people, it is a good idea to consult your own health professional first before embarking on one of these schemes. You have no idea how someone with an underlying condition can react to some of the synthetic vitamins pushed by Isagenix. Talk to your GP first. But be acutely aware that the person who sold you Isagenix, is likely to be just like you or me, with no medical background. The person who sold you the product will only be interested in making money from you initial order and autoship orders…….. thats how they get free product and make money.


Do you know how many great, healthy meals you could make for the same price people are spending on this crap? Look for products with less than 5 ingredients, all that you can pronounce…It’s not that tough. Blows my mind. Or how about this…invest in a personal trainer and get your butt off the couch? Here’s another thought, higher a nutritionist or dietitian. It’s not that hard. Eat clean, exercise to the best of your ability, and stop looking for the magic pill.

Take Cleanse for Life daily as part of a balanced diet to promote better health or use it as part of a one- or two-day intermittent fasting deep cleanse for additional benefits. Cleanse for Life should be used as part of an Isagenix System for maximum results. For Daily cleansing, take 2 ounces  twice daily. Enjoy warm or cold. For a deeper, one- or two-day cleanse, take 4 ounces four times throughout the day. Follow with 8 ounces of water. Enjoy warm or cold. Cleansing is most effective with a combination of both daily and deep cleanses.
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